Our Members Institute Of Infectious Disease and Molecular Medicine

He has an active group within the IDM and is based at Stellenbosch University where he directs the Reproductive Immunology Research Consortium in Africa . He is an HIV and TB immunologist focused on studying the immune response to these pathogens in affected tissues, and how this relates to what can be observed from the blood. The research goal is to improve understanding of the immunopathology of TB and HIV, using this information to aid in developing novel therapeutic approaches and diagnostic biomarkers. Areas of interest span the basic sciences of chemistry, biochemistry and microbiology, through to pharmacology and clinical medicine, in the areas of mycobacterial pathogenesis and TB drug discovery research. As a collective, the research groups include over 440 research officers and laboratory, clinical, field site and administrative support staff, 280 Masters and PhD students registered in any year, and 60 or more Postdoctoral Fellows.

He has been an author on over 150 manuscripts in the field of infectious diseases and has an extensive track record in infectious diseases research and practice covering clinical, laboratory and epidemiological aspects. Her research focuses on understanding the role of the developing immune system on the susceptibility of young children to tuberculosis and understanding the role of innate and adaptively acquired CD8+ T cells in host defense to TB. The translational significance of this Parada Creativa Tutoriales research is centred on informing the development of novel vaccines and diagnostics for childhood TB. Her Research Unit is involved with clinical research, epidemiology and operational research, and is a treatment site for HIV infected adults and children. Her research interests include HIV vaccine research, microbicide research and other biomedical and behavioural interventions, and she is an investigator in testing two HIV vaccine regimens in late stage clinical development.

His research is focused on better understanding HIV transmission and disease dynamics with a special concentration on HIV superinfection, latent HIV infection, and the role of the virus in HIV+ organ transplantation. His research interests revolve around investigating immune regulation and dysregulation in the context of HIV infection or exposure. He focuses on Immune ontogeny in HIV exposed infants, placental investigations and pre-term birth, and epithelial immunity in the foreskin.

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